Endocrine Abstracts

Background: Decidualization, a crucial process for successful pregnancy establishment and maintenance, involves endometrial stromal cell differentiation. This process is orchestrated by estradiol (E2), progesterone, and other stimuli that increase intracellular cyclic adenosine monophosphate (cAMP) levels. The progesterone receptor (PR) plays a pivotal role in regulating decidualization, and alterations in its expression are linked to endometrial pathologies. However, the mech...

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...

Background: Heat shock protein 60 (HSP60), a potentially homeostatic antigen, has been shown to be involved in physiological and non-physiological conditions. Experimental data is supporting the role of HSP60 in placental and mitochondrial steroidogenesis. Under stress conditions, HSP60 are translocated into the endothelial-cell plasma membrane and the extracellular space, promoting the atherosclerotic process. Aim: We decided to investigate the associat...

Introduction: Disease-related malnutrition is one of the main factors associated with morbidity and mortality in cancer patients. Furthermore, maintaining and improving muscle mass and function are important to achieve an optimal nutritional status. In this sense, the role of leucine-enriched essential amino acids supplementation for the therapeutic approach to the promotion of muscle anabolism stands out.Methods: 46 cancer patients with malnutrition rec...

Somatostatin (SST)-system is a pleiotropic hormonal system composed by several ligands/receptors that is involved in the regulation of multiple pathophysiological functions. Specifically, certain components of the SST-system are dysregulated in several endocrine-related cancer types compared to control tissues, wherein these alterations seem to influence their development/progression. However, the presence and functional role of neuronostatin (NST) and its putative G-protein c...

Introduction and objectives: In the 4th Workshop on Primary Hyperparathyroidism, it is recommended to perform BMD by DXA of third radius as well as lumbar spine and hip DXA in the initial assessment and follow up of patients with primary hyperparathyroidism. This test is not available in many centers, which means that only T Score values of the lumbar spine and hip are used to certify the absence of osteoporosis in asymptomatic patients wich conservative management is...

Introduction and objectives: Having frequent hypoglycaemias can enable the appareance of severe and unnoticed hypoglycaemias, as well as favouring vascular damage in these patients. Our objective is to evaluate de incidende of severe hypoglycaemias (SH) in patients with Diabetes Mellitus type 1 and the reduction of perceived hypoglycaemias.Material and methods: A prospective study was conducted. Patients attending to their Endocrinology appointments betw...

Glycosylated haemoglobin (HbA1c) is considered the Gold Standard parameter for evaluating long-term glycemic control in individuals with Diabetes Mellitus (DM). The presence of hemoglobin variants or others conditions that modify its glycosylation, can affect the veracity of its measurement. The detection of these hemoglobinopathies and his knowledge by the clinicians is very important for the correct diagnosis and follow-up. We present the case of a patient who presented a he...

Objectives: Different scientific societies recommend performing screening for clinical primary hypothyroidism during the first trimester of pregnancy using local normality ranges of TSH and just in the lack of these, should the American population reference levels be used. Our objective is to determinate the reference range of TSH during the 1st trimester of pregnancy in our healthcare area and the impact of its implantation.Material and metho...

Introduction: Family hypobetalipoproteinemia (HBF) is a rare genetic disorder, in 50% of cases are due to mutations APOB gene, which leads to decreased values of total cholesterol, low density lipoprotein (LDL-cholesterol) and apo-B. It is inherited as an autosomal dominant and heterozygous carriers are usually asymptomatic.Clinical case: Thirty-two-year-old male with abdominal pain and diarrhea associated with food, no relevant history and physical exam...